Researchers at UCLA have launched a new study aimed at increasing access to cancer genetic testing for underrepresented minority women, who have historically faced barriers to such services.
The HERSTORY (Hereditary Exploration and Research for Screening and Testing for Oncology Risks in Women) study will examine inherited genetic predispositions to cancer in women with a family history of the disease. It seeks to improve early detection and prevention opportunities, particularly for minority populations.
“Under-represented minority women, in particular, have been less likely to undergo genetic testing for cancer predisposition, leading to missed opportunities for early detection and prevention,” said Dr. Beth Karlan (above), director of Cancer Population Genetics at UCLA.
The study will integrate clinical data with health records to enhance screening compliance and reduce disparities. It involves genetic counseling, testing and analysis of tumor samples when applicable.
“We’re not just looking at genes, we’re looking at the broader context in which cancer risk develops,” said Dr. Vivian Y. Chang, principal investigator.
Researchers aim to provide a comprehensive understanding of cancer risk factors by incorporating genetic sequencing, tumor testing, and lifestyle assessments. They will also establish a biobank for long-term studies.
“HERSTORY is a huge step towards helping women understand that, and begin to develop their own personal strategies for cancer prevention and treatment,” said Paul Boutros, director of cancer data science at UCLA.
The findings could transform cancer care for women, especially those from underrepresented communities, potentially narrowing gaps in health outcomes.
See “HERSTORY: Democratizing cancer genetic testing to reduce healthcare disparities” (March 27, 2024)
